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KMID : 0604119960020010001
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Journal of the Korean Society of Menopause
1996 Volume.2 No. 1 p.1 ~ p.15
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Histomorphometric Study in Patients with Established Osteroporosis
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정창진/Chung, Chang Jin
박기현/--/배상욱/조동제/송찬호/Park, Ki Hyun/Min, Hae won/Cho, Dong Je/Song, Chan Ho/Park, Yong Ku
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Abstract
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In this study we took iliac bone biopsy in 9 patients with established osteoporosis to assess the correlation between the bone densitormtry and histomorphometric findings and to evaluate the effect of long-term of estrogen therapy(duration of treatment ranged 1 to 6 years). We examined the structural changes that occur in trabecular bone by measurement . of indirect indices of mean trabecular plate thickenss(MTPT ; ranged 91 to 18111m)(normal range ; 13434), Mean trabecular plate separation (MTPS ; ringed 690 to 1925i1m)(normal range ; 785181), mean trabecular bone volume(ranged 11.6 to 26.4%)(normal range ; 265 2.4) and mean osteoid seam width(ranged 1.451 8.7834m)(normal range ; 7.3}1.9). Our data showed that there were a significant negative correlation between MTPS, and Zscores of BMD in vertebral bone and femur neck (rz=0.61, p-0.012 ; r~= 0.45, p=0.04 resctively). There were a also significant correlation between. Z score of vertebral bone densities with osteoid seam width(r2=0.45, p=0.04). TBV was positively correlated with vertebral bone diensities but statistically mmot significant(r-2= 0.44, p=0.0504). Mineral appostional rate was decreased despite of relative long-term treatment of estrogen in most of patients treated with estrogen.
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KEYWORD
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